Qi Chang Selected Research

Neoplasms (Cancer)

2/2024	Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma.
4/2023	PDGFRβ targeted innovative imaging probe for pancreatic adenocarcinoma detection.
1/2023	Novel CD19-specific γ/δ TCR-T cells in relapsed or refractory diffuse large B-cell lymphoma.
1/2023	Discovery and validation of bladder cancer related excreted nucleosides biomarkers by dilution approach in cell culture supernatant and urine using UHPLC-MS/MS.
1/2022	Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma.
1/2022	Discovery of novel benzimidazole derivatives as potent p300 bromodomain inhibitors with anti-proliferative activity in multiple cancer cells.
12/2020	Targeted degradation of CD147 proteins in melanoma.
6/2018	Stapling strategy enables improvement of antitumor activity and proteolytic stability of host-defense peptide hymenochirin-1B.
5/2017	Plasma and brain pharmacokinetics of ganoderic acid A in rats determined by a developed UFLC-MS/MS method.
1/2016	Formulation of 20(S)-protopanaxadiol nanocrystals to improve oral bioavailability and brain delivery.

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Qi Chang Research Topics

Disease

13	Neoplasms (Cancer) 02/2024 - 11/2007
6	Inflammation (Inflammations) 01/2023 - 01/2017
5	Hepatocellular Carcinoma (Hepatoma) 02/2024 - 11/2007
3	Fatigue 12/2022 - 10/2015
3	Cognitive Dysfunction 01/2019 - 12/2013
2	Sleep Wake Disorders 02/2024 - 01/2023
2	Urinary Bladder Neoplasms (Bladder Cancer) 01/2024 - 01/2023
2	Infections 09/2023 - 01/2023
2	Diabetic Foot 09/2023 - 10/2020
2	Disease Progression 01/2023 - 01/2022
2	Melanoma (Melanoma, Malignant) 12/2020 - 01/2020
2	Pulmonary Arterial Hypertension 10/2020 - 01/2019
2	Memory Disorders (Memory Loss) 09/2019 - 06/2016
2	Obesity 01/2018 - 04/2014
2	Hyperlipidemias (Hyperlipidemia) 01/2018 - 04/2014
2	Body Weight (Weight, Body) 12/2016 - 04/2014
1	Acute Lung Injury 03/2024
1	Pulmonary Edema 03/2024
1	Mental Disorders (Mental Disorder) 02/2024
1	Sleep Initiation and Maintenance Disorders (Insomnia) 02/2024
1	Liver Diseases (Liver Disease) 02/2024
1	Non-alcoholic Fatty Liver Disease 02/2024
1	Virus Diseases (Viral Diseases) 01/2024
1	Carcinogenesis 01/2024
1	Stroke (Strokes) 11/2023
1	Brain Diseases (Brain Disorder) 11/2023
1	Atherosclerosis 10/2023
1	Demyelinating Diseases (Demyelinating Disease) 08/2023
1	B-Cell Lymphoma (Lymphoma, B Cell) 07/2023
1	Retrognathia 02/2023
1	Prognathism 02/2023
1	Ischemic Stroke 01/2023
1	Lung Neoplasms (Lung Cancer) 07/2022
1	Acute Liver Failure (Fulminant Hepatic Failure) 01/2022
1	Heart Failure 01/2022
1	Diabetic Nephropathies (Diabetic Nephropathy) 07/2021

Drug/Important Bio-Agent (IBA)

6	Proteins (Proteins, Gene)FDA Link 03/2024 - 12/2020
4	Biomarkers (Surrogate Marker)IBA 10/2023 - 08/2016
3	AntioxidantsIBA 12/2022 - 04/2014
3	Tryptophan (L-Tryptophan)FDA Link 01/2021 - 04/2019
3	FlavonoidsIBA 03/2018 - 07/2013
2	CorticosteroneIBA 02/2024 - 12/2022
2	MelatoninIBA 02/2024 - 01/2023
2	Serotonin (5 Hydroxytryptamine)IBA 02/2024 - 01/2017
2	Messenger RNA (mRNA)IBA 02/2024 - 01/2024
2	benzocycloheptapyridineIBA 07/2022 - 10/2020
2	3- hydroxy- 4- prenyl- 5- methoxystilbene- 2- carboxylic acidIBA 09/2020 - 01/2019
2	PolyphenolsIBA 03/2018 - 10/2015
2	TriterpenesIBA 05/2017 - 12/2007
2	LipidsIBA 12/2016 - 04/2014
2	GlycosidesIBA 07/2013 - 12/2007
1	Leukocyte Elastase (Neutrophil Elastase)IBA 03/2024
1	dehydroandrographolideIBA 03/2024
1	Poly I-CIBA 03/2024
1	CytokinesIBA 03/2024
1	Hypnotics and Sedatives (Sedatives)IBA 02/2024
1	CryptochromesIBA 02/2024
1	Estrogen Receptor betaIBA 02/2024
1	Arylalkylamine N-AcetyltransferaseIBA 02/2024
1	Carrier Proteins (Binding Protein)IBA 02/2024
1	snake venom protein C activatorIBA 02/2024
1	CREB-Binding ProteinIBA 02/2024
1	1-methyladenosineIBA 01/2024
1	Interferon LambdaIBA 01/2024
1	Long Noncoding RNAIBA 01/2024
1	Antiviral Agents (Antivirals)IBA 01/2024
1	HydrogelsIBA 11/2023
1	CholesterolIBA 10/2023
1	Transferrin (beta 2 Transferrin)IBA 10/2023
1	Anti-Bacterial Agents (Antibiotics)IBA 09/2023
1	CuprizoneIBA 08/2023
1	icaritinIBA 08/2023
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 04/2023
1	EnzymesIBA 01/2023
1	dimethylethylsilylimidazoleIBA 01/2023
1	Serum Amyloid A Protein (Serum Amyloid A)IBA 01/2023
1	NucleosidesIBA 01/2023
1	Lysine (L-Lysine)FDA Link 01/2022
1	AntigensIBA 01/2022
1	Monoclonal AntibodiesIBA 01/2022
1	Histones (Histone)IBA 01/2022
1	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2022
1	GlypicansIBA 01/2022
1	AntibodiesIBA 01/2022
1	benzimidazoleIBA 01/2022
1	Protein Kinases (Protein Kinase)IBA 07/2021
1	Adenosine Monophosphate (AMP)IBA 07/2021
1	yuan zhiIBA 01/2021
1	Antidepressive Agents (Antidepressants)IBA 01/2021

Therapy/Procedure

10	Therapeutics 02/2024 - 11/2007
4	Drug Therapy (Chemotherapy) 02/2024 - 08/2018
2	Chinese Traditional Medicine (Traditional Chinese Medicine) 02/2024 - 05/2016
2	Immunotherapy 01/2023 - 01/2022
1	Oral Administration 03/2024
1	Brain-Computer Interfaces 11/2023
1	Precision Medicine 10/2023
1	Osteotomy 02/2023
1	Sagittal Split Ramus Osteotomy 02/2023
1	Distraction Osteogenesis 01/2023
1	Salvage Therapy 01/2023